N-Alkylated Conduritol Aziridines are Potent, Specific and Cell-permeable Covalent Inactivators of Human β-Glucocerebrosidase. Benjamin T. Adams, Sarah Niccoli, Ashley Esarik, Morshed A. Chowdhury, Simon J. Lees, Brian P. Rempel and Christopher P. Phenix.  Chem. Commun., 2015, 51, 11390

Creating and virtually screening databases of fluorescently-labeled compounds for the discovery of target-specific molecular probes.  Kamstra, R.L., Dadgar, S., Wigg, J., Chowdhury, M.A., Phenix, C.P., and Floriano, W.B. Journal of Computer-Aided Molecular Design. Published online Aug 24, 2014.

Carbohydrate-Modified Electrode Surfaces Sensitive to β-Glucosidase Enzyme Activity.  Ervin, E.M., Adams, B.T., Snyman,N., Phenix, C.P., Kariuki, J.K., and Rempel, B.P.   J Int. J. Electrochem. Sci., 9, 2014, 6043-6058.

Prodrug-Inspired Probes Selective to Cathepsin B Over Other Cysteine Cathepsins.  Morshed A. Chowdhury, Ignace A. Moya, Shardul Bhilocha, Cody C. McMillan, Brady G. Vigliarolo, Ingeborg Zehbe, and Christopher P. Phenix.  Journal of Medicinal Chemistry, 57(14), 2014, 6092-104.

High intensity focused ultrasound technology, its scope and applications in therapy and drug delivery.  Phenix, C.P., Togtema, M., Zehbe, I. and Curiel, L.  Journal of Pharmacy & Pharmaceutical Sciences 17(1), 2014, 136-53.

Noninvasive imaging of Enzyme Replacement Therapy using PET: Proof of Concept For Gaucher Disease.  Phenix, C.P., Rempel, B.P., Colobong, K. Doudet, D.J., Adam, M.J., Clarke, L.A., and Withers, S.G.  Proceedings of the National Academy of Sciences, USA., 107 (25), 2010, 10842-10847.
*Article was featured in the June 7th, 2010 issue of Chemical and Engineering News.

Isothermal Titration Microcalorimetry Reveals the Cooperative and Noncompetitive Nature of Inhibition of Sinorhizobium meliloti L5-30 Dihydrodipicolinate Synthase by (S)-Lysine.  Phenix, C.P. and Palmer, D.R.J.  Biochemistry, 47,(30), 2008, 7779–7781. *Article was one of Biochemistry’s “most accessed” rapid report of 2008.

Structural, functional and calorimetric investigation of MosA, a dihydrodipicolinate synthase from Sinorhizobium meliloti L5-30, does not support involvement in rhizopine biosynthesis.  Phenix, C.P., Nienaber, K., Tam, P.H., Delbaere, L.T.J. and Palmer, D.R.J.  ChemBiochem, 9,(10), 2008, 1591-1602.

Crystallization, X-ray diffraction, and structure solution of MosA, a dihydrodipicolinate synthase from Sinorhizobium meliloti L5-30. Leduc, Y. A., Phenix, C.P., Puttick, J., Nienaber, K., Palmer, D.R.J. and Delbaere, L.T.J. Acta Crystallographica F, 62, 2006, 49-51.

Stereoselective oxidation of protected inositol derivatives catalyzed by inositol dehydrogenase from Bacillus subtilis. Daniellou, R., Phenix, C.P., Tam, P.H., Laliberte, M.C and Palmer, D.R.J. Organic and Biomolecular Chemistry, 3, 2005, 401-403.

MosA, a Protein Implicated in Rhizopine Biosynthesis in Sinorhizobium meliloti L5-30, is a Dihydrodipicolinate Synthase. Tam, P.H., Phenix, C. P. and Palmer, D.R.J.  Journal of Molecular Biology, 335(2), 2004, 393-397.

Teaching

Course Instructor

Chemistry 3271 and Biology 3272 (“Biochemistry II”)
Lakehead University, January – April 2015

Chemistry 3251 and Biology 3252 (“Biochemistry I”)
Lakehead University, September – December 2013

Chemistry 3251 and Biology 3252 (“Biochemistry I”)
Lakehead University, September – December 2012

Chemistry 3271 and Biology 3272 (“Biochemistry II”)
Lakehead University, January – April 2011

Chemistry 4710/5311 (“Drug Design Module”)
Lakehead University, February 2011 and 2012

Guest Lecturer

Chemistry 4131/5131 (“Intro to Medical Imaging) 4 Lectures on PET molecular imaging
Lakehead University, Feb 2012 and Feb 2015

Psychology 100 (“Introduction to Psychology”) 1 Lecture on PET tracers for brain imaging
University of Regina, October, 2012

Chemistry 3271 and Biology 3272 (“Biochemistry II”) 2 Lectures on Tyrosine Kinase Receptors and Her2 Cancer
Lakehead University, January – April 2010

bio-organic chemistry PET imaging probes for imaging enzyme activity radiochemistry

Ph.D. in Chemistry (2007)
University Of Saskatchewan
Saskatoon, Saskatchewan

Bachelor of Science Dual Major Degree in Chemistry and Biochemistry (2000)
University of Regina
Regina, Saskatchewan